Since acetic acid is very soluble in water, it is easily separated from the aspirin product. In this experiment, you will measure the melting point of your synthesized asa product, salicylic acid, a crushed aspirin tablet, and pure asa from a manufacturer. Though aspirin has numerous benefits, there are several adverse affects as well. The synthesis of aspirin chemistry science fair project. Heating should be continued until the solution is clear. Aspirin acetylsalicylic acid is a painrelieving compound familiar to virtually all students. Performs the synthesis of acetylsalicylic acid aspirin purification by recrystallization and using melting point to confirm identity. This compound had the medicinal properties of salicylic acid, an extract of willow bark. It is the twostep synthesis of aspirin starting from oil of wintergreen. Theory aspirin, acetylsalicylic acid, was first synthesized in 1893 by felix hofmann, a chemist for the german firm of bayer. The synthesis of aspirin from oil of wintergreen is an example of one of. To verify the identity of the aspirin, completely dissolve.
Synthesis of aspirin synthesis purification characterization. One of the most widely used nonprescription drugs is aspirin. The reaction that is used for the synthesis is shown below. Synthesis and analysis of acetyl salicylic acid amy chan chem 290 section 1 november 25, 2002. H 2 so 4 use a dropper, h 2 so 4 is highly corrosive and swirl the flask gently until the salicylic acid dissolves heat the flask gently on the steam bath for at least 10 minutes. Jeana greaves chem3301112 june 19, 20 synthesis of aspirin from methyl salicylate introduction the synthesis of aspirin acetyl salicyclic acid began with methyl salicylate and sodium hydroxide as the reagent. Synthesis of aspirin lab report 2989 words bartleby. Over the course of the first semester and the beginning of the second, our general chemistry students synthesize two organic substances aspirin and methyl. As a current student on this bumpy collegiate pathway, i stumbled upon course hero, where i can find study resources for nearly all my courses, get online help from tutors 247, and even share my old projects, papers, and lecture notes with other students. Synthesis of aspirin ppt green chemistry filtration. Synthesis of aspirin background aspirin, which ranks as the most widely used drug in the united states, is one of a series of salicylic acid esters that has been known since antiquity to have therapeutic effects. This is not surprising when one considers the medicinal applications for aspirin. An experiment is described that is suitable for the early portion of the laboratory in a general chemistry course and integrates organic examples. Pdf the synthesis and analysis of aspirin semantic scholar.
Company replaced the phenol group with an ester group. Preparation, purification and analysis of aspirin acetylsalicylic acid. This experiment will demonstrate the preparation of aspirin. Synthesis of aspirin lab report 1101 words 5 pages. This paper describes the first of our organic synthesis experiments, the synthesis, purification, and qualitative spectroscopic characterization of aspirin. Aspirin is one of the milder and least expensive pain relievers available. Aspirin synthesis your team of scientists has been hired by the drug research division of santa monica pharmaceuticals, a new startup company formed by some smc alumni. Aspirins chemical name is acetylsalicylic acid, and it is synthesized from the reaction of acetic anhydride with salicylic acid in the presence of phosphoric acid as a catalyst. In fact, many cultures have used plants containing significant amounts of these compounds in medications to relieve. Synthesizing aspirin and oil of wintergreen purpose in this experiment, you will synthesize acetylsalicylic acid, commonly known as aspirin, and methyl salicylate, oil of wintergreen, from salicylic acid. Synthesis of salicylic acid from oil of wintergreen.
The use of aspirin had its origin in the 18th century, when it was found that an extract from the. Tinjauan pustaka esterifikasi adalah reaksi pengubahan dari suatu asam. Pdf preparing a pure aspirin acetylsalicylic acid researchgate. Compound molecular weight hazards density melting point salicylic acid 8. Synthesis in this experiment, aspirin will be produced by reacting salicylic acid with acetic anhydride, a derivative of acetic acid that has similar chemicals properties to acetic acid, but reacts more rapidly and efficiently. Synthesis of aspirin report data collected and subsequent calculations to all equipment should be returned to the correct location after use. Synthesis of aspirin experiment chemistry libretexts. The temperature of an alcohol thermometer was equilibrated in a beaker of room temperature tap water. Waste salicylic acid should be disposed of in the solid waste container. Please attribute this work as being created by the north c. Synthesis of aspirin adapted from bettelheim objective. Aspirin is an analgesic pain reliever, an antipyretic fever reducer, and antiinflammatory medicine. In the presence of moisture, aspirin may decompose hydrolysis into salicylic acid and acetic acid. Aspirin given shortly after a heart attack decreases the risk of death.
In the united states, more than 15,000 pounds are sold each year. Preparation of acetylsalicylic acid aspirin background one of the most widely used nonprescription drugs is aspirin. The purpose of this experiment is to synthesize a common organic product called acetylsalicylic acid aspirin, and to become familiar with the optimum conditions needed for successful yields. Synthesis of aspirin and oil of wintergreen the purpose of this experiment was to employ techniques to synthesize aspirin and oil of wintergreen and to purify crude aspirin via recrystallization. After synthesis and analysis, it will be determined if the crude and recrystallized samples were composed solely of either salicylic acid, acetylsalicylic acid, or a combination of both 3. Synthesis of aspirin ppt free download as powerpoint presentation. Synthesis of aspirin lab report and analysis odinity. A greener approach to aspirin synthesis using microwave irradiation.
The synthesis of aspirin has been a popular experiment in organic chemistry teaching laboratories and even in some introductory chemistry laboratories 1. Allow the flask to stand at room temperature until. The antiplatelet activity of aspirin has resulted in a new use for an old drug. To synthesize acetylsalicylic acid aspirin, purify it, and determine the percent yield. Experiment 8 synthesis of aspirin aspirin is an effective analgesic pain reliever, antipyretic fever reducer and antiinflammatory agent and is one of the most widely used nonprescription drugs. Calculate the mass of crude aspirin that you collected. Aspirin is superior to salicylic acid for oral dosage in that the latter is very bitter, and causes stomach. To become familiar with the role of synthetic chemistry through the production of aspirin. In june 1971 nature published a seminal paper by john vane and priscilla piper, inhibition of prostaglandin synthesis as a mechanism of action for aspirinlike drugs. Antiinflammatory inhibition of the synthesis of prostaglandins. Aspirin alters the oxygenase activity of prostaglandin synthetase by moving the acetyl group to a terminal amine group4. Aspirin, also known as acetylsalicylic acid asa, is a medication used to reduce pain, fever, or inflammation. Aspirin is one of the most widely used nonprescription drugs in the world, with over 50 million pounds consumed annually.
The mechanism for this synthesis provides examples of three major classes of chemical reactions. Compare the melting points of your aspirin and pure aspirin. The synthesis of aspirin chemistry science fair project experiments, chemistry models, exhibition ideas, expo topics for kids and also organics chemistry science ideas for cbse, icse, middleschool, elementary school for 5th, 6th, 7th, 8th, 9th and high school students. Organic synthesis of aspirin chemistry formal lab essay sample. To determine the purity of the aspirin or acetaminophen. You have been asked to evaluate a simple organic synthesis for aspirin and to determine if the synthesis merits further funding by santa monica pharmaceuticals. Aspirin acetylsalicylic acid is the most common medicinal drug in use today. This reaction is the reverse of the synthesis reaction.
Aspirin is a drug which is widely used today to deal with the symptoms of many minor illnesses ranging from general relief from aches and pain. Aspirin synthesis tap water was heated on a steam bath in a 250 ml beaker. Tujuan percobaan memahami reaksi esterifikasi fenol memahami reaksi pembuatan aspirin mampu melakukan uji kadar aspirin hasil reaksi 2. Organic synthesis of aspirin chemistry formal lab essay. This figure mainly reflects purchase of 16,000 tons of aspirin tablets or 80 million tablets a year. Prostaglandins were found to be responsible for pain and blood clotting. The synthesis and characterization of aspirin part 1 purpose. The polar oxygen accepts the electrons from now positively charged hydrogen. Pdf this aim of this experiment focuses on the synthesis of pure aspirin acetylsalicylic acid from ethanoic anhydride and salicylic acid while. Calculate the percent yield of aspirin amount collected theoretical yield x 100% what is the melt point of your dried aspirin. This aim of this experiment focuses on the synthesis of pure aspirin acetylsalicylic acid from ethanoic anhydride and salicylic acid while using concentrated sulfuric acid as a catalyst for the. Synthesis of aspirin aspirin is the single most manufactured drug in the world. The purity of the product will be confirmed by measuring its melting point range. Store the aspirin in the desicooler and determine the percent yield of the synthesis by taking the actual yield and dividing it by the theoretical yield, determined from the original amount of salicylic acid used.
You will be able to see how two very different organic compounds can be made from the same common starting material. Aspirin may help to decrease the progression of athero. Aspirins chemical name is acetylsalicyl ic acid, and it is synthesized from the reaction of acetic anhydride with salicylic acid in the presence of phosphoric acid as. Chan 1 introduction acetyl salicylic acid, commonly known as aspirin, is one of the most common synthetic medicines.
One of the most consumed drugs production in the us is 10 million kgyear aspirin. Synthesis of aspirin introduction aspirin is one of the milder and least expensive pain relievers available. Specific inflammatory conditions which aspirin is used to treat include kawasaki disease, pericarditis, and rheumatic fever. We will prepare aspirin by reacting salicylic acid 1 with an excess of acetic.